![]() Equilibration of serum and tissue levels occurs at approximately 6 to 8 hours. Children generally require higher concentrations of digoxin.Īfter oral administration, there is an early rise in serum concentration. A number of factors can alter normal absorption, distribution, and bioavailability of the drug, including naturally occurring enteric bacteria in the bowel, presence of food in the gut, strenuous physical activity, ingestion of quinine or quinidine, and concomitant use of a wide range of drugs. These therapeutic effects are produced through a network of direct and indirect interactions upon the myocardium, blood vessels, and the autonomic nervous system.ĭigoxin is well absorbed after oral administration and is widely distributed to tissues, especially the heart, kidney, and liver. Digoxin therapy also results in stabilized and slowed ventricular pulse rate. Digoxin improves the strength of myocardial contraction, and results in the beneficial effects of increased cardiac output, decreased heart size, decreased venous pressure, and decreased blood volume. Digoxin is widely prescribed for the treatment of congestive heart failure and various disturbances of cardiac rhythm. Compounds in the digitalis family of glycosides consist of a steroid nucleus, a lactone ring, and a sugar.
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